ACTN4 IHC & FISH

ACTN4肺癌免疫组织化学法(IHC)及荧光原位杂交法(FISH)的辅助生物标志物分析

东莞上元生物科技提供专业医师及临床研究人员辅肌动蛋白4(ACTN4)的体外伴随诊断试剂,包含免疫组织化学法 (IHC) 及荧光原位杂交法 (FISH)。我们的体外伴随诊断试剂由ISO13485認證的亚诺法生技股份有限公司給予技術支持,提供高質量分析物特异性试剂 (ASR, analyte specific reagent)等級與GMP等級的單株抗體與FISH探針。

ACTN4 是一种与细胞运动、侵袭生长及肿瘤转移有关的肌动结合蛋白。ACTN4 蛋白的过度表现及基因放大,与肺癌、卵巢癌、胰脏癌的预后、化疗抗药性、侵袭 1 至 3 期有关。由ACTN4 单株抗体 IHC 染色及 FISH 探针杂交检验所获得的统计显着性与临床相关性信息,可协助病理学家及临床研究人员进行疾病及治疗处置。

ACTN4 IHC & FISH

 ACTN4 DNA and Protein Detection in Lung Adenocarcinoma
FISH   IHC
 
Human lung adenocarcinoma stained with ACTN4 DNA Probe.   Human lung adenocarcinoma stained with ACTN4 monoclonal antibody.
 
 ACTN4 Lung Adenocarcinoma Clinical Studies
ACTN4 FISH positive cases showed significantly poorer prognosis than negative cases in Stage I lung adenocarcinoma.
Noro R et al. Ann Oncol. (2013)
In ACTN4 IHC positive group of Stage-II/IIIA patients with lung adenocarcinoma, prognosis was significantly higher in the ADJ subgroup compared with the observation subgroup.
Miura N. et al. Oncotarget (2016)

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