Technologies


Circulating Tumor Cell (CTC) Capture and Release

Retrieval of circulating tumor cells (CTCs) is a powerful tool for identifying and tracking cancer transformation and metastasis in translational research and clinical applications. CytoQuest™ CR platform utilizes antibody immobilized, nanopillar arrays with thermo-sensitive chip to capture the CTCs, and a specially designed thermal control device to release the CTCs. Monoclonal antibodies targeting specific surface biomarkers of tumor cells can be flexibly interchanged to accommodate the biomarker switch in cell progression. The derived CTCs can be used for downstream cell culture, protein biomarker characterization, and/or gene analyses via fluorescence in situ hybridization (FISH), microarray, and next generation sequencing (NGS).
 

 
CytoQuest™ CR

 

 

CytoQuest™ CR system, SCx™ spiral chamber, HBx™ micromixer, and TCx™ thermal control are trademarks and pending patents of Abnova Corporation.


Circulating Fetal Cell (CFC) Capture and Isolation

Isolation of circulating fetal cells (CFCs) from maternal peripheral blood has been a major goal for non-invasive prenatal diagnosis. Up until now, engineering difficulties and ineffective bioreagents and system integrations have resulted in inconsistent fetal cell capturing and purity, hampering its long-sought prenatal application and deployment in the commercial setting. Abnova develops and provides GMP bioreagents and system solutions for isolation of CFCs as early as 7 week of gestation, thereby providing access to the complete fetal nuclear genome for genetic analysis via fluorescent in situ hybridization (FISH), microarray, and next generation sequencing (NGS).
 

 
CytoQuest™ CR


 
Prenatal Testing vs. Diagnosis


 
  Amniocentesis Chorionic Villus Sampling (CVS) Cell-free DNA Circulating Fetal Cell
Sample Fetal Cells Placental Tissues Mixtures of Fetal and Maternal DNA Fetal Cells
Coverage High High Low
T13, T18, T21 & Sex
High
Accuracy High High High for T21 High
Timing 16 weeks 10 weeks >9 weeks >7 weeks
Invasive Yes Yes No No
Risks to Fetus Yes Yes No No
Testing vs. Diagnosis Diagnosis Diagnosis Testing Diagnosis
 

CytoQuest™ CR system, SCx™ spiral chamber, HBx™ micromixer, and TCx™ thermal control are trademarks and pending patents of Abnova Corporation.

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