ACTN4 IHC & FISH

ACTN4肺癌免疫組織化學法(IHC)及螢光原位雜交法(FISH)的輔助生物標誌物分析

東莞上元生物科技提供專業醫師及臨床研究人員輔肌動蛋白4(ACTN4)的體外伴隨診斷試劑,包含免疫組織化學法 (IHC) 及螢光原位雜交法 (FISH)。我們的體外伴隨診斷試劑由ISO13485認證的亞諾法生技股份有限公司給予技術支援,提供高質量分析物特異性試劑 (ASR, analyte specific reagent)等級與GMP等級的單株抗體與FISH探針。

ACTN4 是一種與細胞運動、侵襲生長及腫瘤轉移有關的肌動結合蛋白。ACTN4 蛋白的過度表現及基因放大,與肺癌、卵巢癌、胰臟癌的預後、化療抗藥性、侵襲 1 至 3 期有關。由ACTN4 單株抗體 IHC 染色及 FISH 探針雜交檢驗所獲得的統計顯著性與臨床相關性資訊,可協助病理學家及臨床研究人員進行疾病及治療處置。

ACTN4 IHC & FISH

 ACTN4 DNA and Protein Detection in Lung Adenocarcinoma
FISH   IHC
 
Human lung adenocarcinoma stained with ACTN4 DNA Probe.   Human lung adenocarcinoma stained with ACTN4 monoclonal antibody.
 
 ACTN4 Lung Adenocarcinoma Clinical Studies
ACTN4 FISH positive cases showed significantly poorer prognosis than negative cases in Stage I lung adenocarcinoma.
Noro R et al. Ann Oncol. (2013)
In ACTN4 IHC positive group of Stage-II/IIIA patients with lung adenocarcinoma, prognosis was significantly higher in the ADJ subgroup compared with the observation subgroup.
Miura N. et al. Oncotarget (2016)

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